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Advance All-day revitalizing Moisturizer

Aloe vera

Relaxing, Calming & Soothing skin

Maintain skin’s moisture balance

 

 

 

Benefits

  • Provides a healthy, bright, and clean complexion by increasing the amount of oxygen delivered to your skin.
  • Fights back against pimples. Aloe Vera’s anti-inflammatory properties calm the skin, reduce redness, and minimize the visibility of acne scars.
  • Aloe Vera helps to reduce redness, puffiness and rash on the skin’s surface caused by environmental irritants.
  • Helps your skin looking firm and wrinkle free, while minimizing the appearance of dark spots.
  • Moisturizes without leaving behind excess oil and grease. Great for oily and sensitive skin types.
  • Comforts skin that has been overly exposed to harmful UV light thanks to its cooling properties

 

Credits: http://blog.evoderma.com/

Skinesia’s exclusive ‘Neoderma complex’

 

An advance anti-aging/anti-wrinkle technology,

 Gives your skin a timeless look.

 

THE NEEDLE-FREE” COLLAGEN AND ELASTIN FILLER.

 

 

                          Neoderma complex® is an anti-aging active product that induces in the dermis the synthesis of specific key proteins involved in the maintenance of the skin structure by fibroblasts (collagen type I, collagen type III, tropoelastin and elastin).

 

  • Neoderma complex® is an active ingredient containing Methylglucoside-6-phosphate (MG6P), Proline, Lysine and Copper. Methylglucoside-6-phosphate is a biotechnology-activated sugar that provides energy after its metabolization.
  • Proline, copper and lysine à collagen and elastin synthesis
  • Neoderma complex® à reactivate aged fibroblasts (senescent) à increased viability and procollagen I synthesis , very quickly just after 3 days of treatment.
  • One study showed, Neoderma complex® à stimulate fibroblasts in aged living skin à synthesis of collagen type I, collagen type III, tropoelastin and elastin, very quickly just after 6 and 11 days of treatment àyounger skin properties
  • The clinical investigation performed on human volunteers confirms the effects of Neoderma complex®. Neoderma complex® treatment.
  • Neoderma complex® à promotes the synthesis in dermis of key proteins involved in skin structure and elasticity: collagen type I, collagen type III, tropoelastin and elastinàrejuvenation of human aged skin.

 

 

 

Neoderma complex®’s mode of Action

 

 

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Conclusions on clinical investigations

 

The clinical investigation has shown that after 15 days to 60 days of treatment, the cream with 1% Neoderma complex® significantly statistically improves the following clinical parameters:

  • • Increasing collagen density
  • • Improvement of skin micro relief by reducing skin anisotropy
  • • Increasing skin firmness and elasticity
  • • Reduction of the depth and volume of wrinkles

 

 

 
 

 

 

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Neoderma complex® improves by about 7.5 times the skin collagen density after 15 days and gives equivalent results after 60 days.

 

 
 

 

 

 

 

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Neoderma complex® at 1% improves the skin microrelief by reducing the anisotropy of the skin respectively by 25 and 2.5 times after 15 days and 60 days

 
 

 

 

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Neoderma complex® 1% in comparison to placebo induced after 15 days and 60 days statistically

significant improvements of skin elasticity respectively of +60%* and +44%

 

 
 

 

 

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          Neoderma complex® 1% significantly improves skin firmness (by 12 to 13 times) and elasticity (at least 44% corresponding at least to 1.6 times) at D15 and D60 in comparison to placebo.

 

 

 

 

 

 
 

 

 

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Neoderma complex® at 1% significantly decreases the depth and volume of the wrinkles at D15 in comparison to placebo (-15% of wrinkles’ depth and -13% of wrinkles’ volume).

 

 
 

 

 

                                                                                                      

Summary of results from clinical investigation performed on human volunteers.

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Reference: Induchem, Switzerland

Panthenyl Triacetate and Naringenin

 

  • Panthenyl Triacetate and Naringenin, naturally extracts from Citrus aurantium reduce skin redness and skin trans-epidermal water loss (TEWL).

 

 

What is Panthenyl Triacetate and Naringenin?

 

 

 

How do Panthenyl Triacetate and Naringenin work?

     

 

 

Panthenyl Triacetate and Naringenin inhibit JAK/STAT cytokines activated signaling pathway in keratinocytes. The communication between the keratinocyte and the immune cell is interrupted with the result of inhibiting skin irritation, providing an immediate soothing effect.

 

 

  • 80% Inhibiting skin irritation, providing an immediate soothing effect.

 

                        

  • 99% inhibits chemokines synthesis

 

 

                      

  • 97% Inhibits cytokines synthesis.

 

 

 

significantly decreases

  • skin redness
  • skin trans-epidermal water loss (TEWL)

 

 

Conclusion

 

  • Panthenyl Triacetate and Naringenin, naturally extracts from Citrus aurantium significantly reduce skin redness and skin trans-epidermal water loss (TEWL).
  • 80% Inhibiting skin irritation, providing an immediate soothing effect. Perfectly use after laser skin treatment, after sun exposure or even irritated and sensitive skin.
  • 99% inhibits chemokines synthesisàhelp irritated and sensitive skin
  • 97% Inhibits cytokines synthesisà improve irritated and sensitive skin

 

Phytosphingosine

 

  • Phytosphingosine(PS) is a natural sphingolipid in human skin  that maintain skin barrier function , as well as,  anti-microbial and anti-inflammatory properties

 

Phytosphingosine properties

 

Interleukin 1 alpha (IL-1α): Marker of inflammation

Peptide expressed by many cells including epidermal keratinocytes

  • Key role in regulation of acute inflammation with a prime position in the cytokine cascade
    • Switches on production of additional cytokines, prostaglandins.
  • Important mediator for the induction of a variety of skin disorders :
    • Allergic & irritant dermatoses
    • Photoallergic & phototoxic skin reactions including sunburn
    • Degradation of collagen matrix via expression of matrix metalloproteases (MMP‘s)
    •  

 

The Anti-Inflammatory and Anti-Microbial Properties of Phytosphingosine work synergistically.

 

 

Phytosphingosine on acne patients

 

 

 

Abbreviations used:

• PS = Phytosphingosine

• BPO = Benzoyl Peroxide

 

 

                        Phytosphingosine

  • is naturally present in the skin
  • shows excellent clinical results on Acne
  • has two anti-acne properties, which work synergistically:
  • anti-inflammatory activity
  • anti-microbial activity
  • Anti-Cellulite
  • Cellulite caused by inflammation of the conjunctive tissueà leading to swelling
  • Phytosphingosine à Anti-Cellulite

-  reduction of swelling

-  promotion of blood circulation

  • Prevent & reduce skin darkness, puffiness, dark eye circle
  • Prevention of puff formationà prevent swelling in the fat puffiness
  • Promotion of blood circulation
  • Strengthening of the microcapillaries/ disappearance of black circlesà reduce skin darkness, dark eye circle
  • Repairs and protects even the fragile eye area and successfully treat the appearance of lines, dryness, puffiness and dark circles

 

Shiso Extract 

 

Shiso Extract is a natural anti-allergic & immune regulating substance derived from the green perilla leaves grown in Hokkaido, Japan. Clinically proven that effectively treats skin irritation, allergy, acute&chronic inflammation and dermatitis.

 

Traditional uses of Shiso leaves have included herbal medicinal applications such as; a digestive aid, to treat acne and topical dermatitis, for intestinal disorders, and as an

anti-bacterial substance.

 

 

Immune regulation

 

As immune regulator, Shiso Extract has

an anti-inflammatory value inhibiting the

production of TNF (Tumor Necrosis Factor).

TNF is recognized as an important host

defense factor. TNF production and its

activity is linked with allergic reaction,

therefore inhibiting overproduction of

TNF is an advantageous step toward the

suppression of acute and chronic inflammation.

TNF is one of the essential factors in the

human body, however, prolonged exposure

to TNF might contribute to the wasting of

the host which is associated with many

chronic disease states. Shiso Extract stabilizes the over-stimulated immune system and restore it to its normal activity level without side effect.

 

Anti-Allergic effects

 

Research shows Shiso Extract

is effective in all the types of

allergy. Shiso Extract has been

found to inhibit IgE overproduction,

as well as TNF overproduction,

therefore it is also effective on asthma

 

 

Clinical use

 

Shiso Extract is used for the

treatment of some allergy diseases

such as atopic dermatitis and hey-

fever at several medical institutes

in Japan, and suppression of

inflammation or itch.

 

CLINICAL OBSERVATIONS

USAGE OF CREAM CONTAINING SHISO EXTRACT