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Advanced White Repair serum

Phytosphingosine

 

  • Phytosphingosine(PS) is a natural sphingolipid in human skin  that maintain skin barrier function , as well as,  anti-microbial and anti-inflammatory properties

 

 

Phytosphingosine properties

 

Interleukin 1 alpha (IL-1α): Marker of inflammation

Peptide expressed by many cells including epidermal keratinocytes

  • Key role in regulation of acute inflammation with a prime position in the cytokine cascade
    • Switches on production of additional cytokines, prostaglandins.
  • Important mediator for the induction of a variety of skin disorders :
    • Allergic & irritant dermatoses
    • Photoallergic & phototoxic skin reactions including sunburn
    • Degradation of collagen matrix via expression of matrix metalloproteases (MMP‘s)

 

 

The Anti-Inflammatory and Anti-Microbial Properties of Phytosphingosine work synergistically.

 

 

Phytosphingosine on acne patients

 

 

 

Abbreviations used:

• PS = Phytosphingosine

• BPO = Benzoyl Peroxide

 

 

                        Phytosphingosine

  • is naturally present in the skin
  • shows excellent clinical results on Acne
  • has two anti-acne properties, which work synergistically:
  • anti-inflammatory activity
  • anti-microbial activity
  • Anti-Cellulite
  • Cellulite caused by inflammation of the conjunctive tissueà leading to swelling
  • Phytosphingosine à Anti-Cellulite

   -  reduction of swelling

   -  promotion of blood circulation

  • Prevent & reduce skin darkness, puffiness, dark eye circle
  • Prevention of puff formationà prevent swelling in the fat puffiness
  • Promotion of blood circulation
  • Strengthening of the microcapillaries/ disappearance of black circlesà reduce skin darkness, dark eye circle
  • Repairs and protects even the fragile eye area and successfully treat the appearance of lines, dryness, puffiness and dark circles

Tetrapeptide-30

 

 

 

  • Safely for all kinds of skin types, even sensitive skin
  • Visibly diminishes dark spots
  • Improves the evenness of skin tone
  • Brightens skin
  • Prevent dark spots formation
  • Reduce signs of aging and photo damage
  • Reduce acne lesions
  • Alleviates melasma
  • Protection and repair of sensitive and dry skin
  • Help your skin looking brighter & younger than you ever feel before

 

 

 

 

How does tetrapeptide-30 work?

  • Has an indirect mechanism influencing keratinocyte/melanocyte communication and by this melanogenesis.

 

 

Scientifically proven effects

  • Tetrapeptide-30 helps to protect epidermal keratinocytes from UV induced inflammation.
  • Safely inhibits the pigmentation process

 

 

 

 

Skin lightening study –Test result

 

 

 

 

 

Anti-age spot study with tetrapeptide-30

  • Significant visibly fading of age spots at treatment area.

 

 

 

Tetrapeptide-30 visibly diminishes age spots much better than vitamin C or Sodium Ascorbyl Phosphate(SAP) and shows a boosting effect for Sodium Ascorbyl Phosphate.

 

 

 

Tetrapeptide-30 lightens and evens skin tone.

 

 

 

Tetrapeptide-30

  • Significantly improves the overall appearance & evenness of skin tone.
  • Significantly reduces acne lesion.

 

 

  • Dramatically improve melasma

 

 

 Conclusion

 

Tetrapeptide-30

  • Safely for all kinds of skin types, even sensitive skin
  • Visibly diminishes dark spots
  • Improves the evenness of skin tone
  • Brightens skin
  • Prevent dark spots formation
  • Reduce signs of aging and photo damage
  • Reduce acne lesions
  • Alleviates melasma
  • Protection and repair of sensitive and dry skin
  • Help your skin looking brighter & younger than you ever feel before

 

Reference: Evonik Industries,Germany

 

Arbutin

 

 Natural, Safe, and Effective,

One of the best whitening agents of this century.

 

  • αArbutin is a new type of active compound for beautifying and whitening the skin.
  • α-Arbutin can be rapidly absorbed into the skin and selectively inhibit the activity of tyrosinase, therefore obstruct the melanogenesis without altering the normal growth of the epidermal cell or inhibiting the expression of tyrosinase itself.
  • α-Arbutin also promotes decomposition and excretion of melanin, therefore, reduces the deposition of skin pigment and removes color spots and freckles.
  • The α-Arbutin involved processes neither produce hydroquinone, nor have other side effects including toxicity, irritation and sensitization of the skin.
  • These properties result in α-Arbutin being the safest and most effective skin-whitening and spot-removing substance developed to date. α-Arbutin also helps disinfect and moisturize the skin and eliminate inflammation.
  • It also helps the wounded skin recover.

 

 

Mechanisms of Skin Whitening

 

                       White and radiant skin has always been one of the gold standards for a beauty. It is well known that the color of skin is due to level of melanin and rate of blood flow in and under the skin. Color spots and skin pigmentation are directly related to melanin pigmentation.

                      Melanin is produced by melanocytes in top layer of the skin. It protects prickle cells and basal cells beneath from UV rays by absorbing and reflecting irradiation energy. Melanin shields basal cells from being hurt, burnt or mutated. The unharmed basal cells can then propagate and differentiate to form healthy and elastic skin. If the capability of melanin synthesis decreases, the skin will become more sensitive to UV rays. This is believed to be the reason that skin cancers occur more often in European countries than that in African countries.

                      Therefore, a safe and effective whitening product must not alter melanocytes while inhibiting melanin formation. α-Arbutin is exactly such a product.

 

How does α-Arbutin work?

  • α-Arbutin inhibits the activity of mammalian tyrosinase through a mixed mechanism of action.
  • It selectively inhibits tyrosinase without affecting the genetic expression of tyrosinase itself and it doesn’t disturb the normal growth of the epidermic cells and melanocytes.
  • Further more, the α-Arbutin involved processes do not produce hydroquinone, which makes α-Arbutin a safe and highly effective tyrosinase inhibitor.

 

 

 

 

Human Skin Melanin Study

 

The study compare the effect of α-Arbutin with that of β-Arbutin in 34 volunteers demonstrated that 1% α-Arbutin has a faster and more pronounced skin lightening effect than 7% β-Arbutin. After one month of application the melanin levels of α-Arbutin users were significantly lower than those of before the application, which meant that α-Arbutin not only inhibited the stain formation, it also helped to dissolve the pigmentation. Theses two mechanisms make α-Arbutin superior to its beta arbutin.

 

 

The L value is an index for measuring skin color. When skin color becomes lightened, L value also increases. Human Skin Melanin Study on 34 volunteers demonstrated that α-Arbutin helped inhibit the stain formation in the process of stain forming, while it obviously helped accelerate dissolve the pigmentation in the process of spontaneous regression.

 

 

Ceramide complexes

 

Human skin-identical ceramides.

Giving your skin what it needs!

 

- Supports the renewal of the skin's natural protective layer

and forms an effective barrier against moisture loss.

- Particularly suitable for long term protection and repair of

sensitive and dry skin

-Balanced lipid mixtures to build strong skin barrier function are the important key.

 

 

Primarily the outermost layer of the epidermis – the stratum corneum, provides the protection of the skin.

 

 

 

The arrangement of the lipids in the stratum corneum is a key process for the formation of the skin barrier

 

 

Stratum corneum lipid composition

  • The major lipid classes in the stratum corneum are Ceramides, cholesterol and fatty acids

 

 

 

Stratum corneum lipid organization.

  • The sandwich model is the new representation of the membrane bilayer structure of the stratum corneum lipids

 

 

 

Ceramides and their molecular structures are crucial for the organization of the membrane bilayer structure

 

 

 

The crucial role of ceramides in the skin.

  • Skin ceramide levels decrease rapidly with increasing age.

  • In dry skin, the total Ceramide content is decreasing.
  • In dry skin, there is a deficiency in phytosphingosine based Ceramides.

 

 

Ceramide III is able to reproduce the membrane bilayer structure of stratum corneum lipids

 

 

 

Ceramide III improves hydration of skin and provides long lasting effect.

 

 

 

Ceramide III decreases roughness of skin and prevents roughness of damaged skin.

 

 

Ceramide III prevents irritation of damaged skin by regulating the barrier function of the skin.

 

 

Ceramide III help damaged skin to recover from dryness.

 

Benefits of Ceramide III formulated with cholesterol and fatty acids on damaged skin (clinical evaluation)

 

 

 

Ceramide VI rejuvenates skin by decreasing roughness and reducing flakes.

 

 

Conclusion

Multiple and unique benefits of skin-identical ceramides

  • Suitable for all skin types
  • Ideal for healthy, dry, stressed, aging and sensitive skin
  • Mimic the multi-lamellar structure of skin lipids due to its unique

stereo-chemical configuration.

  • Multi-fold action:

-Maintenance of skin hydration with long lasting effect

-Decrease and prevention of skin roughness

-Prevention of skin irritation

-Repair of dry skin conditions

  • Normalizes the skin’s natural desquamatory process
  • Supports the renewal of the skin's natural protective layer and forms an effective barrier against moisture loss
  • Particularly suitable for long term protection and repair of sensitive and dry skin

 

Reference: Evonik Industries,Germany